Friday, September 27, 2019

Updates to the Tuberculosis Section of the Adult and Adolescent Opportunistic Infections Guidelines

 

 

 

     
   
 
 

At-a-Glance

 
Issue No. 22 | September 27, 2019 View HTML version
 
 
News and Features

Updates to the Tuberculosis Section of the Adult and Adolescent Opportunistic Infections Guidelines

The Mycobacterium tuberculosis Infection and Disease section of the Guidelines for the Prevention and Treatment of Opportunistic Infections in Adults and Adolescents with HIV has been updated. The Panel updated this section to reflect the availability of results from a number of new studies in tuberculosis (TB) diagnostics, therapeutics, pharmacology, and drug resistance. Several key highlights include:
  • The 3HP regimen (weekly isoniazid plus rifapentine for 3 months) for the treatment of latent tuberculosis infection (LTBI) is now recommended as an alternative regimen when provided as self-administered therapy or directly observed therapy.
  • Four months of daily rifampin monotherapy is now recommended for the treatment of LTBI in patients who cannot receive isoniazid.
  • When dolutegravir is given with concurrent rifampin, it is recommended that the dose be increased to 50 mg twice daily.
  • Bictegravir is not recommended to be given with rifamycin-containing TB treatment.
  • Isoniazid preventive therapy is not recommended for pregnant women until after delivery unless they are close contacts of a known patient with active TB disease.
  • Prednisone is no longer recommended for the treatment of TB pericarditis.
  • Isoniazid-monoresistant TB should be treated with 6 months of rifampin, pyrazinamide, ethambutol, and either levofloxacin or moxifloxacin.
  • For patients at high risk for developing TB-associated immune reconstitution inflammatory syndrome (TB-IRIS), pre-emptive prednisone is recommended as adjunctive therapy with the initiation of antiretroviral therapy.
 
 
     
 
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Thursday, September 26, 2019

NIH awards contracts to advance tuberculosis immunology research

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09/26/2019 04:30 PM EDT

Research will help advance TB vaccine development.

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NIH Awards Contracts to Advance Tuberculosis Immunology Research

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Thursday, September 26, 2019

NIH Awards Contracts to Advance Tuberculosis Immunology Research

Scanning electron micrograph of Mycobacterium tuberculosis

NIAID has awarded $30 million in first-year funding to establish new centers for tuberculosis immunology research to accelerate progress in TB vaccine development. The contract awards establish three Immune Mechanisms of Protection Against Mycobacterium tuberculosis (IMPAc-TB) Centers to elucidate the immune responses needed to protect against TB-causing bacteria.

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Preventing falls | Food allergy | Sleep gene | Dilated eye exam | Fetal alcohol exposure

Learn how to prevent falls, what you can do about a food allergy, why it is important to have a dilated eye exam, and more.
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Thursday, September 26, 2019

 

Preventing Falls

A hand holding on to a handrail.

Each year millions of Americans, especially older adults, go to the emergency department after an injury from a fall. Learn what you can do to prevent falls. (From NIH News in Health)


Food Allergy

Peanuts and a bowl of peanut butter.

Food allergies can be very difficult for those living with the allergy and their families. Read more about NIH's commitment to food allergy research. (From NIH's NIAID)


Gene Identified In People Who Need Little Sleep

A man waking up.

Scientists identified a gene that causes people to naturally sleep less than six and a half hours each night without any apparent ill effects. (From NIH Research Matters)


Dilated Eye Exam

An eye doctor shining a flashlight into a patient's eye.

A dilated eye exam is the best thing you can do for your eye health. Discover why. (From NIH's NEI)


Fetal Alcohol Exposure

A woman's hands forming the shape of a heart over her pregnant stomach.

Fetal alcohol exposure occurs when a woman drinks while pregnant. Alcohol can disrupt fetal development at any stage during a pregnancy. (From NIH's NIAAA)



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New NIH Program Provides Comprehensive Treatment for Inherited Blood and Immune Diseases

Streamlined program integrates expertise from many medical specialties and related basic science disciplines.
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Thursday, September 26, 2019

New NIH Program Provides Comprehensive Treatment for Inherited Blood and Immune Diseases

Aerial view of the NIH Clinical Center

Aerial view of the NIH Clinical Center. Credit: National Institutes of Health

People with inherited diseases of the blood and immune system can now receive treatment at the NIH Clinical Center through a new, streamlined program that integrates expertise from many medical specialties and related basic science disciplines. Immunologists, transplant specialists, geneticists and hematologists from across NIH are collaborating in the Blood and Immune Deficiency–Cellular Therapy Program. These physicians will deliver state-of-the-art and experimental care to people with rare blood and immune system diseases through a unified approach to assessing, treating and monitoring patients and the centralized tracking of treatment outcomes.

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New NIH program provides comprehensive treatment for inherited blood and immune diseases

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09/26/2019 11:30 AM EDT

Streamlined process integrates expertise from many medical specialties and related basic science disciplines.

This email was sent to myhcistech.healthnews360@blogger.com using GovDelivery Communications Cloud on behalf of: National Institutes of Health (NIH) · 9000 Rockville Pike · Bethesda MD 20892 · 301-496-4000 / TTY 301-402-9612 GovDelivery logo