Study adds to growing body of evidence that EVs can enable one type of cell to influence the behavior of an entirely different cell type.

Tuesday, November 20, 2018 Mast Cells Cause Liver Disease through Protein Shuttled via Extracellular Sacs Credit: Ed Uthman from Houston, TX, USA (CC BY 2.0), via Wikimedia Commons New research by NIH investigators demonstrates for the first time that a bone marrow-derived cell, the mast cell, can cause disease in a solid organ through the transmission of small sacs of molecules through the bloodstream. Specifically, the study shows that in people with a rare disorder called systemic mastocytosis, some of these sacs, known as extracellular vesicles, travel from mast cells to liver cells and deliver a protein that causes liver disease. Published online in the Proceedings of the National Academy of Sciences in October, the study adds to a growing body of evidence that extracellular vesicles can enable one type of cell to influence the behavior of an entirely different cell type. National Institute of Allergy and Infectious Diseases  |  National Institutes of Health Update your subscriptions, modify your password or e-mail address, or stop subscriptions at any time on your Subscriber Preferences Page. You will need to use your e-mail address to log in. If you have questions or problems with the subscription service, please contact subscriberhelp.govdelivery.com. This service is provided to you at no charge by National Institute of Allergy and Infectious Diseases (NIAID). This email was sent to myhcistech.healthnews360@blogger.com using GovDelivery Communications Cloud on behalf of: National Institute of Allergy and Infectious Diseases · 5601 Fishers Lane · Bethesda, MD 20892 · 1-866-284-4107