Tuesday, November 13, 2018

NIAID Scientists Illuminate Causes of Hepatitis B Virus-Associated Acute Liver Failure

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Tuesday, Nov. 13, 2018

NIAID Scientists Illuminate Causes of Hepatitis B Virus-Associated Acute Liver Failure

HPV-ALF

NIAID scientists and their Italian collaborators have found that hepatitis B virus (HBV)-associated acute liver failure (ALF) results from an uncommon encounter between a highly mutated HBV variant and an unusual immune response in the patient's liver. HBV-ALF is a rare condition that can turn fatal within days without liver transplantation. The researchers made the discoveries by examining liver samples taken from four patients who developed HBV-ALF, one of the most dramatic clinical syndromes in medicine, according to the research team. They hope their work provides a model of how the disease develops and will lead to new diagnostic, treatment and prevention strategies.

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