Thursday, August 1, 2019

Experimental Respiratory Syncytial Virus Vaccine Prompts Antibody Surge

Structure-Based Candidate Designed by NIAID Scientists
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Thursday, August 1, 2019

Experimental Respiratory Syncytial Virus Vaccine Prompts Antibody Surge

RSV large

A novel experimental vaccine against respiratory syncytial virus (RSV), a leading cause of severe respiratory illness in the very young and the old, has shown early promise in a Phase 1 clinical trial. The candidate, DS-Cav1, was engineered and developed by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, who were guided by their atomic-level understanding of the shape of an RSV protein. An interim analysis of study data showed that one dose of the investigational vaccine prompted large increases in RSV-neutralizing antibodies that were sustained for several months. The findings are reported in Science.

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