Monday, March 9, 2020

Drug-Delivery Technology Leads to Sustained HIV Antibody Production

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Monday, March 9, 2020

Drug-Delivery Technology Leads to Sustained HIV Antibody Production

Illustration of a virus delivering genetic material into a cell

Illustration of a virus delivering genetic material into a cell. Credit: National Human Genome Research Institute

A new approach to direct the body to make a specific antibody against HIV led to sustained production of that antibody for more than a year among participants in a NIAID clinical trial. This drug-delivery technology uses a harmless virus to deliver an antibody gene into human cells, enabling the body to generate the antibody over an extended time. With further development, such a strategy could be applied to prevent and treat a wide variety of infectious diseases.

Researchers reported the findings today at the 2020 Conference on Retroviruses and Opportunistic Infections (CROI).

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