Thursday, June 11, 2020

Brain Cells Can Harbor and Spread HIV Virus to the Body

NIH-funded study highlights the importance of addressing the brain in HIV cure strategies

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Brain Cells Can Harbor and Spread HIV Virus to the Body

NIH-funded study highlights the importance of addressing the brain in HIV cure strategies

Image showing HIV infection of CD4+ T cells in the mouse brain. Credit: Al-Harthi et al. (2020)

Researchers have found that astrocytes, a type of brain cell, can harbor HIV and then spread the virus to immune cells that traffic out of the brain and into other organs. HIV moved from the brain via this route even when the virus was suppressed by combination antiretroviral therapy, a standard treatment for HIV. The study, conducted by researchers at Rush University Medical Center in Chicago and published in PLOS Pathogens, was funded by the National Institutes of Health.

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