Friday, July 24. 2020 NIAID researchers and their international colleagues have identified the first heritable risk factor for severe anaphylaxis, a potentially life-threatening allergic reaction. Having multiple copies of the alpha tryptase gene, a relatively common genetic trait first described by NIAID scientists in 2016 and now known as hereditary alpha tryptasemia, was linked to a higher risk of severe anaphylaxis among people with insect sting allergy and certain mast cell disorders. Findings from the study, published online in the Journal of Allergy and Clinical Immunology, also suggest a potential mechanism underlying this association. |
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