Wednesday, July 8, 2020

NIH Study Defines Features of Rare Disease, Suggests Potential Therapy

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NIH Study Defines Features of Rare Disease, Suggests Potential Therapy

Graphic illustrating mechanisms of autoimmunity in ICL

Autoantibodies—immune system proteins that target and react with a person's own tissues or organs—are prevalent in people with idiopathic CD4 lymphopenia (ICL) and may contribute to disease progression, a NIAID study has found. There are currently no specific therapies for ICL, a rare disease characterized by persistently low numbers of CD4 T cells, which leads to increased risk of severe infections. The new findings, recently published online in the Journal of Clinical Investigation, suggest that therapies that suppress autoantibodies may hold potential for treatment of the condition.

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