Investigators create first test-tube system where early events in HIV replication take place

Tuesday, October 20, 2020 NIAID-Supported Research Unveils Characteristics of Key Steps in HIV Life Cycle Illustration summarizing the steps researchers took to make HIV reverse transcription and integration happen in a test tube. Credit: Janet Iwasa and Devin Christensen, University of Utah Health The conditions under which HIV reverse transcription and integration occur have been under debate for many years. Central to that debate has been the role of the cone-shaped "capsid" nestled inside the spherical membrane that encloses the virus. In new NIAID-supported research, the first test-tube system where early events in HIV replication take place clarifies that reverse transcription must happen inside a largely intact capsid. Removing the capsid from the test tube and adding soluble material from human cells enabled a complete copy of HIV DNA to fully integrate into circular DNA. These findings are published in the journal Science. National Institute of Allergy and Infectious Diseases  |  National Institutes of Health Update your subscriptions, modify your password or e-mail address, or stop subscriptions at any time on your Subscriber Preferences Page. You will need to use your e-mail address to log in. If you have questions or problems with the subscription service, please contact Subscriber Help. This service is provided to you at no charge by National Institute of Allergy and Infectious Diseases (NIAID).                             This email was sent to myhcistech.healthnews360@blogger.com using GovDelivery Communications Cloud on behalf of: National Institute of Allergy and Infectious Diseases · 5601 Fishers Lane · Bethesda, MD 20892 · 1-866-284-4107