Friday, January 15, 2021 How Do Fungal Infections Take Hold? Rare Disease Offers New Insights In healthy mucosal tissues (left), the immune system prevents fungal infections, with T cells (yellow and purple) playing a key protective role. In AIRE deficiency (right), aberrant T-cell responses damage the outermost layer of cells, helping fungal infections take hold. Credit: NIAID By studying the rare disease APECED, NIAID researchers and colleagues uncovered an unexpected immune mechanism that promotes susceptibility to fungal infections of the mucous membranes. Their findings, published in the Jan. 15 issue of Science, suggest potential therapies for people with APECED and pave the way for work to investigate these tissue-specific immune responses in other diseases. National Institute of Allergy and Infectious Diseases  |  National Institutes of Health Update your subscriptions, modify your password or e-mail address, or stop subscriptions at any time on your Subscriber Preferences Page. You will need to use your e-mail address to log in. If you have questions or problems with the subscription service, please contact Subscriber Help. This service is provided to you at no charge by National Institute of Allergy and Infectious Diseases (NIAID).                             This email was sent to myhcistech.healthnews360@blogger.com using GovDelivery Communications Cloud on behalf of: National Institute of Allergy and Infectious Diseases · 5601 Fishers Lane · Bethesda, MD 20892 · 1-866-284-4107