Thursday, April 22, 2021

Clinical Trial of Therapeutics for Severely Ill Hospitalized COVID-19 Patients Begins

Patients with Acute Respiratory Failure May Now Enroll in NIH-Sponsored Trial
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Thursday, April 22, 2021

Clinical Trial of Therapeutics for Severely Ill Hospitalized COVID-19 Patients Begins

SARS-CoV-2 virus particles

A new clinical trial to test therapeutics in severely ill COVID-19 patients has begun enrolling participants. ACTIV-3 Critical Care is a master protocol designed to test multiple therapeutics at once. It will begin by testing Zyesami, an formulation of a synthetic vasoactive intestinal peptide which may have anti-inflammatory properties, and the antiviral remdesivir (Veklury). This placebo-controlled trial may reveal new treatment regimens for Acute Respiratory Distress Syndrome (ARDS), a life-threatening condition associated with SARS-CoV-2 infection.

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