Tuesday, April 13, 2021

NIAID Trial of Anti-CD14 Antibody to Treat COVID-19 Respiratory Disease Begins

The laboratory-created antibody, called IC14, binds to a human protein, CD14, found on the surface of immune cells.
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Tuesday, April 13, 2021

NIAID Trial of Anti-CD14 Antibody to Treat COVID-19 Respiratory Disease Begins

Transmission electron microscope image of SARS-CoV-2 emerging from human cells

Transmission electron microscope image of SARS-CoV-2 emerging from human cells. Credit: NIAID

NIAID has launched a clinical trial to test the safety and efficacy of an investigational monoclonal antibody for treating people who are hospitalized with respiratory disease and low blood oxygen due to infection with SARS-CoV-2, the virus that causes COVID-19. The laboratory-created antibody, called IC14, binds to a human protein, CD14, found on the surface of immune cells circulating in the blood and airway fluid and that also circulates as a stand-alone protein. CD14 helps immune cells recognize pathogens and injured or dying cells, alerting the immune system to danger and prompting it to respond.

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