Wednesday, May 26, 2021

NIAID scientists find that Salmonella use intestinal epithelial cells to colonize the gut

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Wed., May 26,2021

NIAID scientists find that Salmonella use intestinal epithelial cells to colonize the gut

Scanning electron micrograph of Salmonella Typhimurium invading a human epithelial cell.

NIAID scientists have found that the immune system's attempt to eliminate Salmonella bacteria from the gastrointestinal (GI) tract instead facilitates colonization of the intestinal tract and fecal shedding. The study, published in Cell Host & Microbe, involves a bacterium that causes about 1.35 million infections, 26,500 hospitalizations, and 420 deaths in the United States every year. Contaminated food is the source for most of these illnesses. Their study is part of a long-term look into how Salmonella bacteria establish and maintain a foothold in the GI tract of mammals. The findings are an example of how the pressure exerted by the host immune response can drive the evolution of a pathogen, and vice versa.

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