Wednesday, June 30, 2021

Investigational Vaccine for Malaria Gives Strong, Lasting Protection

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Wednesday, June 30, 2021

Investigational Vaccine for Malaria Gives Strong, Lasting Protection

malaria sporozoites

Two U.S. Phase 1 clinical trials of a candidate malaria vaccine have found that the regimen conferred unprecedentedly high levels of durable protection when volunteers were later exposed to disease-causing malaria parasites. The vaccine combines live parasites with either of two widely used antimalarial drugs—an approach termed chemoprophylaxis vaccination. A Phase 2 clinical trial of the vaccine is now underway in Mali, a malaria-endemic country. If the approach proves successful there, chemoprophylaxis vaccination, or CVac, potentially could help reverse the stalled decline of global malaria.

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