Wednesday, August 3, 2022

NIAID Macaque Study Shows 2 Omicron VOCs Cause Less Severe Disease in Lungs, Nasal Area than Delta

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Wednesday, Aug. 3, 2022

NIAID Macaque Study Shows 2 Omicron VOCs Cause Less Severe Disease in Lungs, Nasal Area than Delta

Omicron v Dellta

This transmission electron micrograph shows SARS-CoV-2 Omicron virus particles (purple) replicating in an infected cell. (NIAID)

NIAID scientists have shown in a rhesus macaque study model that disease caused by SARS-CoV-2 Omicron BA.1 and BA.2 variants of concern (VOC) is less severe in the lungs and nasal areas than the Delta VOC. The findings, published on the preprint server bioRxiv, are consistent with what is found in people infected with Omicron VOCs and will help scientists better understand how SARS-CoV-2 immunity affects disease severity – ultimately allowing them to improve COVID-19 vaccines and treatments. Omicron is the first VOC reported that has caused less severe disease in people than preceding VOCs.

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