Tuesday, October 4, 2022

NIH-Supported Clinical Trial of Phage Therapy for Cystic Fibrosis Begins

The trial will evaluate the impact of a bacteriophage mixture on Pseudomonas aeruginosa in volunteers with CF
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Tuesday, October 4, 2022

NIH-Supported Clinical Trial of Phage Therapy for Cystic Fibrosis Begins

Pseudomonas aeuroginosa

Bacteriophages, or "phages," are viruses which naturally attack specific kinds of bacteria. Researchers have long recognized that they could hold potential as a therapeutic for treating bacterial infections, especially those with resistance to antibiotics. However, there are still many gaps in researchers' knowledge about these useful viruses. A new clinical trial, conducted by the NIAID-supported Antibacterial Resistance Leadership Group, will evaluate the impact of a bacteriophage mixture in volunteers with cystic fibrosis (CF) who carry Pseudomonas aeruginosa bacteria in their lungs. P. aeruginosa is a common cause of lung infections in people with cystic fibrosis, and is becoming difficult to treat due to antibiotic resistance.

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