Monday, Nov. 14, 2022 An experimental therapeutic cancer vaccine induced two distinct and desirable immune system responses that led to significant tumor regression in mice, report NIAID investigators in Cell. They found that intravenous (IV) administration of the vaccine boosted the number of cytotoxic T cells capable of infiltrating and attacking tumor cells and engaged the innate immune system by inducing type I interferon. The innate immune response modified the tumor microenvironment, counteracting suppressive forces that otherwise would tamp down T-cell action. Dubbed "vax-innate" by the scientific team, the approach achieves an important goal in the quest for more effective immunotherapeutic vaccines for cancer. |
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