Tuesday, November 1, 2022

Monoclonal Antibody Prevents Malaria Infection in African Adults

Antibody protected clinical trial participants during 6-month malaria season
NIH/NIAID Template Banner

Tuesday, Nov. 1, 2022

Monoclonal Antibody Prevents Malaria Infection in African Adults

Study participant receives infusion of antibody or placebo

A study participant in Kalifabougou, Mali receives an intravenous infusion of either the monoclonal antibody or a placebo. Credit: Safiatou Doumbo

One dose of an antibody drug safely protected healthy, non-pregnant adults from malaria infection during an intense six-month malaria season in Mali, Africa, a NIAID clinical trial has found. The antibody was up to 88.2% effective at preventing infection over a 24-week period, demonstrating for the first time that a monoclonal antibody can prevent malaria infection in an endemic region. These findings were published in The New England Journal of Medicine and presented at the American Society of Tropical Medicine & Hygiene 2022 Annual Meeting in Seattle.

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