Wednesday, January 18, 2023

NIAID-led Study Identifies Bacteria Signaling for Nerve Repair in Mice

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Wednesday, Jan. 18, 2023

NIAID-led Study Identifies Bacteria Signaling for Nerve Repair in Mice

bacteria nerve repair

This confocal microscope image shows a ring of nerve regeneration occurring in mice (bottom right). Scientists exposed the mice to commensal bacteria (Staphylococcus aureus), then a month later the mice sustained an ear injury (biopsy). Ten days later the scientists took the image to document the nerve fiber recovery progress associated with immune cell responses (gold staining). (Credit: NIAID)

A team of NIAID-led researchers has identified a mechanism in mice in which the immune system and commensal bacteria – microbes that naturally colonize tissues – help repair damaged sensory neurons within the skin. That means recovering awareness to touch, temperature, pain and itch. They hope their findings, published in Cell, could lead to therapies that stimulate recovery in people following skin injury and limit damage from chemotherapy and chronic diseases, such as diabetes. The findings add to the growing knowledge of how the microbiota – the trillions of beneficial microbes living harmoniously on our skin and inside our gut – bridge biological systems to benefit living beings.

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