Wednesday, January 18, 2023

Probiotic Markedly Reduces S. aureus Colonization in Phase 2 trial

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Wednesday, Jan. 18, 2023

Probiotic Markedly Reduces S. aureus Colonization in Phase 2 trial

Otto probiotic

This image shows methicillin-resistant Staphylococcus aureus bacteria (yellow) being ingested by a neutrophil (purplish blue). Credit: NIAID

NIAID scientists and colleagues in Thailand have found that a probiotic was safe and effective at controlling Staphylococcus aureus bacterial colonization in people, highlighting a promising alternative approach to using antibiotics. The Phase 2 trial, involving 115 people, resulted in a 96.8% S. aureus reduction in the stool and a 65.4% reduction in the nose. Importantly, the researchers found that the probiotic used, Bacillus subtilis, did not harm the gut microbiota while markedly reducing S. aureus colonization in trial participants. The microbiota includes the trillions of beneficial microbes living harmoniously on our skin and inside our gut. The study is published in The Lancet Microbe. The researchers plan to continue their work by testing the probiotic in a larger and longer trial.

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