Friday, Feb. 10, 2023 | NIAID-funded scientists have developed an inhibitor that can specifically prevent severe allergic reactions to peanut in a mouse model designed to mimic human peanut allergy. In a study published in Science Translational Medicine, the researchers describe how the inhibitor protected the mice from allergic reactions to peanut, but not other allergens, for up to two weeks when given before exposure. The inhibitor also prevented severe reactions even when given shortly after the onset of an allergic reaction. The study is from researchers at Indiana University, the University of Notre Dame, and Vanderbilt University. Their work involves a new approach where the treatment acts by inhibiting the allergen from starting a reaction. Though additional testing is necessary, the findings suggest the inhibitor could be a potential novel preventive measure for peanut allergy in people. Peanut-induced allergy can cause symptoms ranging from swelling to life-threatening anaphylaxis. There are few preventive therapies other than strict dietary avoidance or oral immunotherapy, neither of which are successful in all patients. |
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