Thursday, May 25, 2023

COVID-19 News: Findings May Aid Early Identification of COVID-19 Patients at Highest Risk of Death

Scientists identified biologic features linked to the course & severity of COVID-19.
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Thursday, May 25, 2023

New Findings May Aid Early Identification of COVID-19 Patients at Highest Risk of Death

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Transmission electron micrograph of SARS-CoV-2 Omicron virus particles (pink) replicating within the cytoplasm of an infected CCL-81 cell (teal). Credit: NIAID

NIAID-funded researchers have identified sets of biologic features that define specific components of the immune system associated with the course and severity of COVID-19 in 540 hospitalized adult patients. Disease severity was characterized by the amount of respiratory support needed over time. The investigators identified features that distinguished patients whose disease course was severe from those whose course was more moderate. The scientists also identified features in people with critical illness that distinguished those who died from those who recovered by their 28th day after hospital admission. The scientists hope their findings and data will ultimately help doctors rapidly identify those COVID-19 patients at highest risk of death, allowing for prompt provision of lifesaving care. The findings were published in the journal Cell Reports Medicine.

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