Tuesday, June 13, 2023

A Secret to Health and Long Life? Immune Resilience, NIAID Grantees Report

Immune system attribute helps explain why some people live longer, healthier lives than others.
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Tuesday, June 13, 2023

A Secret to Health and Long Life? Immune Resilience, NIAID Grantees Report

Three quarters of a pale yellow, spherical object on a soft pink background.

Colorized scanning electron micrograph of a T cell. One immune resilience metric is based on the relative quantities of two types of T cells. Credit: NIAID

NIAID-supported researchers have pinpointed an attribute of the immune system called immune resilience that helps explain why some people live longer and healthier lives than others. Immune resilience involves the ability at any age to control inflammation and to preserve or rapidly restore immune activity that promotes resistance to disease. The investigators discovered that people with the highest level of immune resilience lived longer than others. People with greater immune resilience also were more likely to survive COVID-19 and sepsis as well as to have a lower risk of acquiring HIV infection and developing AIDS, symptomatic influenza, and recurrent skin cancer. In addition, women were more likely to have optimal immune resilience than men. The journal Nature Communications published the research today.

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