Thursday, June 1, 2023

NIAID Service IDs 3,000 Natural Products for Disease-Fighting Potential

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Thursday, June 1, 2023

NIAID Service IDs 3,000 Natural Products for Disease-Fighting Potential

screening service

Caption: This scanning electron micrograph shows Staphylococcus aureus bacteria in gold. Credit: NIAID

 

Natural products have historically provided a wealth of opportunities to fight bacterial and fungal infections. In a new study published in ACS Infectious Diseases, NIAID used its preclinical screening service to help National Cancer Institute scientists evaluate natural products for disease-fighting potential against bacteria and fungi. Target pathogens include drug-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans. Collaborating with the NCI Program for Natural Product Discovery, the project has screened more than 300,000 natural products and found more than 3,000 sources for additional investigation and potential development.  The proof-of-concept study identified many new samples to investigate that had not previously been known to fight bacterial and fungal infections – and opens the potential to find more unknown natural antibiotic compounds.

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