Wednesday, September 6, 2023

NIAID Investigating Concerning K. pneumoniae Strains

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Wednesday, Sept. 6, 2023

NIAID Investigating Concerning K. pneumoniae Strains

mbio K pneumoniae

Caption:  A human neutrophil (red) containing ingested Klebsiella pneumoniae (purple). NIAID

 

The emergence of new bacterial Klebsiella pneumoniae strains, which can cause dangerous human disease, have NIAID scientists and colleagues retracing work done in recent decades against methicillin resistant Staphylococcus aureus (MRSA) bacteria. Much like MRSA, K. pneumoniae has moved from primarily infecting people in hospital settings to now infecting otherwise healthy people in community settings. Two strains of concern are known as hypervirulent (hvKp) and multidrug resistant (MDR hvKp). A new study published in mBio shows that the human immune system is effective at fighting MDR hvKp, but not hvKp. Researchers are hoping to identify why there is a different immune response and how the findings can lead to treatments to prevent or decrease disease severity.

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