Wednesday, October 25, 2023

Leishmania Parasite Uses Host Antibodies in Insect Vector’s Blood Meal to Breed

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Wednesday, Oct. 25, 2023

Leishmania Parasite Uses Host Antibodies in Insect Vector's Blood Meal to Breed

An illustration showing the sand fly and human stages of leishmaniasis.

Caption: An illustration showing the sand fly and human stages of leishmaniasis. Credit: NIAID.

Spooky science: Inside a bloodsucking insect, a parasite uses the blood of mammals to get more fit to infect unsuspecting people. In this case, the story is more troubling because it's a real threat. The parasite is Leishmania, which causes leishmaniasis, a primarily tropical and subtropical disease that can cause skin lesions and organ damage, and can be fatal. The bloodsucking insect that spreads Leishmania parasites is the sand fly, a small, biting vector that infects humans and other mammals with the parasite. Researchers at NIAID found that the parasite uses antibodies from the human or mammalian host to form mating clumps in the sand fly gut, prompting a process that allows the parasite to adapt and become more suited to infecting people. The findings were published today in Nature.

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