Wednesday, December 13, 2023

NIAID Scientists Find Infectious SARS-CoV-2 in Patient Blood

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Wednesday, Dec. 13, 2023

NIAID Scientists Find Infectious SARS-CoV-2 in Patient Blood

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Colorized scanning electron micrograph of a cell (green) infected with SARS-CoV-2 virus particles (orange), isolated from a patient sample. Credit: NIAID

New findings published in the Annals of Internal Medicine confirm that infectious SARS-CoV-2 virus travels in blood throughout the body, infecting cells at various locations. Scientists affiliated with NIAID and the NIH Clinical Center describe in a case report the discovery of live SARS-CoV-2 in the blood of a 76-year-old woman who died of COVID-19 in fall 2020. Previously, several research teams had identified fragments of the virus in blood and tissue, but never live virus with the ability to replicate. "Our case proves that replication-competent SARS-CoV-2 can traffic in blood during COVID-19 and seed tissues throughout the body," the report states. The researchers say more studies are needed to determine the characteristics of bloodborne SARS-CoV-2 in people with mild illness; waning immunity; and those who were recently vaccinated or became infected following vaccination. 

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