Thursday, December 7, 2023

NIH Clinical Trial of Tuberculous Meningitis Drug Regimen Begins

Six-month multidrug regimen being evaluated against standard treatment
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Thursday, December 7, 2023

NIH Clinical Trial of Tuberculous Meningitis Drug Regimen Begins

Scanning electron micrograph of Mycobacterium tuberculosis (colorized blue), the bacterium which causes TB.  Credit: NIAID

Scanning electron micrograph of Mycobacterium tuberculosis (colorized blue), the bacterium which causes TB. Credit: NIAID

A NIAID-sponsored study to test a new drug regimen for tuberculous meningitis (TBM) began this week in countries where TB is prevalent, with the aim of improving treatment for people with this less common but deadly form of TB. The IMAGINE-TBM trial will compare a 6-month regimen of four drugs with the 9-month, standard-of-care regimen for TBM. IMAGINE-TBM is being implemented through the NIAID-funded Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG).

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