Friday, December 15, 2023

NIH Research Identifies Opportunities to Improve Future HIV Vaccine Candidates

Study suggests greater CD8+ T-cell activity may increase HIV immunity.
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Friday, December 15, 2023

NIH Research Identifies Opportunities to Improve Future HIV Vaccine Candidates

Three large spheres floating against a granulated background. Each sphere has circular and irregularly shaped matter dispersed across its surface.

Layout featuring colorized 3D prints of HIV virus particles (pink with teal surface proteins) and a background image that is a colorized transmission electron micrograph of HIV virus particles (pink) budding and replicating from an H9 T cell (purple). Micrograph captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Note: not to scale. Credit: NIAID

A new study from the HIV-Specific Immunity Section of NIAID's Laboratory of Immunoregulation and colleagues found strong responses from immune cells called CD8+ T cells may play a key role in an effective HIV vaccine. These findings, published in Science, could guide development of future HIV vaccines and immunotherapy approaches.

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