Tuesday, January 30, 2024

Switching to Vegan or Ketogenic Diet Rapidly Impacts Immune System

NIH Study Finds Distinct Immune Responses Occur Quickly When Diets Change, More Research Needed to Determine Health Effects
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Tuesday, January 30, 2024

Switching to Vegan or Ketogenic Diet Rapidly Impacts Immune System

Common foods in foreground, blue background with light blue rod-shaped particles dispersed across the top, and double-helix shape across the middle.

Composite image of gut bacteria and DNA with healthy foods. (Credit: Creative layout by NIAID; incorporates visual elements by Adobe Stock.)

NIH researchers observed rapid and distinct immune system changes in a small study of people who switched to a vegan or a keto diet. Scientists closely monitored various biological responses of people sequentially eating vegan and keto diets for two weeks, in random order. They found that the vegan diet prompted responses linked to innate immunity—the body's non-specific first line of defense against pathogens—while the keto diet prompted responses associated with adaptive immunity—pathogen-specific immunity built through exposures in daily life and vaccination. Metabolic changes and shifts in the participants' microbiomes—communities of bacteria living in the gut—were also observed. More research is needed to determine if these changes are beneficial or detrimental and what effect they could have on diseases such as cancer or inflammatory conditions.

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