Friday, March 1, 2024

New Antibodies Target “Dark Side” of Influenza Virus Protein

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Friday, March 1, 2024

New Antibodies Target "Dark Side" of Influenza Virus Protein

A multicolored globular representation of neuraminidase protein with bound antibodies on a colorful background

A tetramer of the influenza neuraminidase protein (shown in blue and light blue) bound by variable domains of two new human antibodies (shown purple/pink and brown/beige) targeting its "dark side." Viewed along with 4-fold axis of NA tetramer with its catalytic sites facing up. Credit: NIAID

NIAID researchers identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored "dark side" of the neuraminidase (NA) protein head. The antibodies target a region of the NA protein that is common among many influenza viruses, including H3N2 subtype viruses, and could be a new target for countermeasures against flu. The findings were published today in Immunity.

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