Wednesday, March 27, 2024

Stem Cell Changes Rejuvenate Immune System in Aged Mice

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Wednesday, March 27, 2024

Stem Cell Changes Rejuvenate Immune System in Aged Mice

T cell green

Caption: Colorized scanning electron micrograph of a healthy T lymphocyte (green), also known as a T cell. Credit: NIAID

Stem Cell Changes Rejuvenate Immune System in Aged Mice

NIAID, Stanford Exploring Potential for Revitalizing Human Immunity

 

Aging is associated with a reduced ability to generate immune responses against novel infections, as was recently illustrated by the high mortality among older people during the COVID-19 pandemic. Using a mouse model of human aging and disease, NIAID scientists and Stanford University colleagues have shown that immune systems of aged laboratory mice can be made more youthful and effective at fighting disease by depleting a subset of haematopoietic stem cells (HSCs). The researchers think the method they developed may have potential for rejuvenating immunity in elderly people and are pursuing further study. Their findings are published in Nature.

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