Researchers Create Celiac Disease Organoid Model, Find Treatment Target

Model uniquely maintains tissue structure, immune features of human intestine.

Wednesday, July 24, 2024 Researchers Create Organoid Model of Celiac Disease, Find Treatment Target Immunofluorescence staining of an intestinal organoid created by the study team. Epithelial cells are white, T cells are yellow, other immune cells are pink, and cell nuclei are blue. Credit: António J. M. Santos, Stanford University School of Medicine NIAID-supported researchers have created an organoid model of celiac disease that enabled them to identify a potential treatment target: an immune-system protein called interleukin 7 (IL-7). The model is unique because it has the tissue structure and immune features of the human intestine, and it mimics celiac disease when exposed to gluten. Scientists hope the model will advance their understanding of how celiac disease develops, which could lead to new treatments. The findings were published today in the journal Nature. National Institute of Allergy and Infectious Diseases  |  National Institutes of Health Update your subscriptions, modify your password or e-mail address, or stop subscriptions at any time on your Subscriber Preferences Page. You will need to use your e-mail address to log in. If you have questions or problems with the subscription service, please contact Subscriber Help. Your subscription may be removed if you do not open our emails for a six-month period.  This service is provided to you at no charge by National Institute of Allergy and Infectious Diseases (NIAID).                             This email was sent to myhcistech.healthnews360@blogger.com using GovDelivery Communications Cloud on behalf of: National Institute of Allergy and Infectious Diseases · 5601 Fishers Lane · Bethesda, MD 20892 · 1-866-284-4107