Tuesday, October 29, 2024

Gene Signature at Birth Predicts Sepsis in Newborns Before Signs Appear

Discovery could facilitate early treatment, obviate need to give antibiotics to all newborns with suspected sepsis but no diagnosis.
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Monday, October 28, 2024

Gene Signature at Birth Predicts Sepsis in Newborns Before Signs Appear

Three-dimensional DNA double helix rests on flat white page with black letters.

Illustration of a DNA double helix resting on a printout of the genetic code letters A, T, C and G. Credit: NHGRI

A four-gene signature detectable in newborns' blood at birth predicts before symptom onset whether a baby will develop sepsis during the first week of life, NIAID-funded researchers report. Sepsis is a potentially life-threatening condition that arises when the body's response to infection injures its own tissues and organs. Using the newly discovered genetic signature to identify newborns who will develop sepsis could facilitate early treatment and obviate the need to give antibiotics to all newborns with suspected sepsis but lacking a definitive diagnosis. The findings are published in the journal eBioMedicine.

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