Friday, January 17, 2025

Vaccine Protective in Mice Against H5N1 Influenza from Cattle

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Friday, Jan. 17, 2025

Vaccine Protective in Mice Against H5N1 Influenza from Cattle

H5N1 RNA flu vax

Three rod-shaped influenza A H5N1 virus particles shown in purple. Credit: CDC and NIAID

An experimental vaccine designed against the highly pathogenic avian influenza H5N1 (HPAI H5N1) virus circulating in U.S. cattle was fully protective in research mice, according to a new study published in Nature Communications. NIAID scientists led the animal study with colleagues from HDT Bio in Seattle who developed the replicating RNA vaccine (repRNA) platform. The findings also suggest that the HPAI H5N1 circulating in the U.S. may be able to evade immunity from older H5N1 viruses. The scientists continue to develop the repRNA vaccine platform, and evaluations in additional animal models are ongoing.

 

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