Wednesday, January 4, 2023

Myocarditis | Chemo Drug Redesign | Hodgkin Lymphoma, 01/04/2023

National Cancer Institute

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Cancer Information Highlights
From the National Cancer Institute
Updating you about cancer causes, prevention, screening, treatment, coping, and more
 
New from NCI
What Causes Immunotherapy's Heart-Related Side Effects?
At the bottom, several layers of heart muscle cells with inflammation. Alpha-myosin protiens project like fingers along the top of the heart muscle cells. T cells float above the alpha-myosin projections and bind to them.   Myocarditis, or inflammation in the heart, is a rare but often fatal side effect of treatment with immune checkpoint inhibitors. Researchers have now found a potential chief cause of this problem: T cells attacking a protein in heart cells called alpha-myosin.
Chemo Drug Redesigned to Avoid Side Effects
The drug DRP-104 remains   Researchers have changed a chemo drug, once abandoned because it caused serious side effects in the gut, so that the drug is only triggered in tumors. After promising results in mice, the drug, DRP-104, is now being tested in a clinical trial.
Advances in Ovarian Cancer Research
An ovarian tumor grown in a mouse using human cells. Special techniques were used to create the high-resolution, 3-D view of the cancer's cell structure and inner workings.   This new page highlights recent advances in research to prevent and treat cancer that starts in the ovaries, fallopian tubes, and the membrane that lines the abdominal cavity (also called the peritoneum).
Targeted Therapy Approved for High-Risk Hodgkin Lymphoma in Young People

Based on an NCI-sponsored clinical trial conducted by the Children's Oncology Group, the Food and Drug Administration (FDA) has approved the drug brentuximab vedotin (Adcetris) in combination with chemotherapy for some young people with Hodgkin lymphoma.
Monoclonal Antibody Approved for Advanced Alveolar Soft Part Sarcoma

A clinical trial led by NCI has resulted in the first approval of a treatment for advanced alveolar soft part sarcoma (ASPS). FDA recently approved the immunotherapy drug atezolizumab (Tecentriq) for the treatment of some adults and children with ASPS.

FDA Approvals
Mirvetuximab Soravtansine-gynx

We've added a drug summary for mirvetuximab soravtansine-gynx (Elahere). FDA recently approved this drug to treat ovarian cancer, fallopian tube cancer, or primary peritoneal cancer that is folate receptor–alpha positive. It is used in adults whose cancer did not respond to or is no longer responding to platinum chemotherapy and who have received one to three types of systemic therapy.
 
Also of Interest
Eating Hints: Before, during, and after Cancer Treatment

This updated booklet describes ways to eat well before, during, and after treatment for cancer. It can help you understand eating problems that may happen and suggests ways to deal with them.
COVID-19: What People with Cancer Should Know

COVID-19 rates are rising. Read the latest on how to protect yourself, including new information from the Centers for Disease Control and Prevention (CDC) about COVID vaccines that target the Omicron variant for children as young as 6 months old. You'll also find information about treatment for people who are more likely to get very sick from COVID-19 and special considerations for people with cancer.
Contact Us for Help

Information specialists at NCI's Cancer Information Service (CIS), NCI's contact center, are available to help answer your cancer-related questions in English and Spanish. Reach us by phone, chat, or email.

 

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Available Now: Population and Clinical Database Resources

National Institute on Deafness and Other Communication Disorders

January 4, 2023

Available Now: Population and Clinical Database Resources

A graph linearly ascending with icons of people.

The NIDCD Epidemiology and Statistics Program team has compiled a list of databases that may be useful to investigators interested in NIDCD mission areas. Epidemiological studies and surveys provide a wealth of data related to the prevalence, incidence, risk factors, and preventive interventions for diseases related to hearing, balance, taste, smell, voice, speech, or language. Much of the data from these studies are publicly available for scientists to leverage as a part of their own research. Check out NIDCD's new Population and Clinical Database Resources webpage to browse example databases by topic, read about the study cohorts for each dataset, and learn how to access the data for your own research.

Explore the databases here »

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Health Information

Hearing, ear infections, etc.

Balance

Taste and smell

Voice, speech, and language

Dr. Wade Chien and staff

Popular Topics

Do you need a hearing test?

Ear infections

Tinnitus

Stuttering

NIDCD now offers an easy way for you to get trusted, up-to-date content for your website. Learn more about content syndication >>


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FYI: Weekly Health Resources for January 4, 2023

Free COVID -19 At-home Tests and More!

January 4, 2023  |  View as a webpage

FYI: Weekly Health Resources

Free COVID-19 At-home Tests are Available Again Online

Free COVID Home Test

The White House has announced a new limited round of free at-home COVID-19 tests for the winter. Households can now order either standard at-home tests or tests that are more accessible for people who are blind or have low vision. Shipping is free.

Older adults and people with disabilities who need support ordering the free at-home tests can contact the Eldercare Locator (800-677-1116) or the Disability Information and Access Line (DIAL, 888-677-1199). 

Learn More 

Funding

Farm-to-School Grant

Grant from the U.S. Department of Agriculture (USDA) to assist eligible entities in implementing farm-to-school programs that improve access to local foods in the USDA Food and Nutrition Child Nutrition Programs.
Deadline is January 6.

Learn More


Distance Learning and Telemedicine Grants

Grant from the USDA to improve telemedicine and distance learning services in rural areas through telemedicine, computer networks, and related advanced technologies.
Deadline is January 30.

Learn More


Centers of Excellence (COE) - Historically Black Colleges and Universities

Grant from HRSA that funds innovative resource and education centers to assist health professions schools in supporting programs of excellence in health professions education for under-represented minority individuals.
Deadline is February 7.

Learn More

 

Ending the HIV Epidemic - Primary Care HIV Prevention

Prevention Grant from the Health Resources and Services Administration (HRSA) providing funding to expand HIV prevention services that decrease the risk of HIV transmission in underserved communities in support of ending the HIV epidemic in the U.S.
Deadline is January 17.

Learn More


Maternal and Child Health (MCH) Nutrition Training Program

Grant from the Health Resources and Services Administration (HRSA) to promote the healthy nutrition of mothers, children, and families by establishing and enhancing nutrition centers of excellence to train future and current MCH nutrition professionals.
Deadline is February 2.

Learn More


Tribal Management Grant Program

Grant from the Indian Health Service (IHS) to assist federally-recognized tribes and tribal organizations in assuming all or part of existing Indian Health Service programs, services, functions, and activities.
Deadline is March 6.

Learn More

Webinars and Other Events

Treatment of Common STIs

Webinar hosted by the MidAtlantic AIDS Education and Training Center.
TODAY, January 4, at 2 p.m. ET.

Register


Introductory/Refresher Virtual Motivational Interviewing Training

Half-day webinar training hosted by the National Council for Mental Wellbeing.
January 12, at 12:00 p.m. ET. 

Register

 

Trauma & Stress Disorders Webinar Series: PTSD & Impact on Parenting

Webinar hosted by the IHS TeleBehavioral Health Center of Excellence.
January 17, at 12:00 p.m. ET.

Register

Safety & Health Training for American Indians & Alaska Natives in the Western U.S.

Webinar hosted by the National Institute of Environmental Health Sciences (NIEHS). January 10, at 2:00 p.m. ET.

Register

Improving Access to Oral Health Care for Tribal and Underserved Communities

Webinar series hosted by HRSA.
January 12, at 2:00 p.m. ET.

Register


Investigation of "Well-Established" Risk Factors for Cognitive Decline and Alzheimer's Disease in Black Americans, Plus a Call for Health Equity Research

Webinar hosted by the National Institute of Health (NIH) National Institute on Aging (NIA).
January 30, at 1:00 p.m. ET.

Register

Resources

NIHB Launches Podcast Series to Increase Healthcare Access in Indian Country

The hope healing

The National Indian Health Board (NIHB) launched a six-episode podcast series to inform American Indian and Alaska Native Tribal citizens and Tribal leaders on healthcare options that offer more care and better care to Indian Country. The Hope + Healing Podcast with the NIHB is a partnership with Indian Country Media and the Centers for Medicare and Medicaid Services (CMS). Together, they will dive deep into topics and interview leaders from Indian Country and experts in Native health.


Learn More

Letter to U.S. Governors from HHS Secretary Xavier Becerra on COVID-19 Resources

HHS

HHS Secretary Xavier Becerra recently released a letter to reiterate the federal government's ongoing commitment to support efforts and provide resources to reduce COVID-19 cases during the winter.

This includes setting up additional mobile and pop-up vaccination sites, surge testing sites, as well as Test to Treat sites where Americans can not only get tested for free, but also can get prescribed and dispensed safe, effective COVID-19 treatments right on site if they test positive and treatment is appropriate for them.

 

Learn More

Clinical Trials

Alzheimer's Disease and Precision Medicine Research Among Native People

This study, sponsored by The University of Colorado, intends to address the gaps in Alzheimer's disease (AD) and precision medicine (PM) research in American Indian and Alaska Native (AI/AN) populations. The study will be conducted in Denver, Colorado.

Learn More

 

Family, Responsibility, Education, Support, and Health for Latino Caregivers

This study, sponsored by the University of California in collaboration with the National Institute of Minority Health and Health Disparities (NIMHD), seeks to collect initial efficacy data on a telehealth family-based behavioral program for Latino children with overweight or obesity, which also includes additional caregiver support, compared with health education. The study will be conducted in La Jolla, California.

Learn More

Workforce Development

SAMHSA Minority Fellowship

The Substance Abuse and Mental Health Services Administration (SAMHSA) is providing a 1-year fellowship for psychiatry residents who are interested in addressing minority psychiatric mental health issues and committed to a career providing culturally sensitive psychiatric services for minority underserved populations. African Americans, Alaska Natives, American Indians, Asian Americans, Hispanics/Latinos, Native Hawaiians, and Pacific Islanders are encouraged to apply.
Deadline for application is February 3.

Learn More

Knowledge Center

Knowledge Center Online Catalog: See our newest acquisitions.

Recommended Reading

In recognition of National Glaucoma Awareness Month, the OMH Knowledge Center is highlighting a small collection of consumer resources and a social media toolkit from the NIH, National Eye Institute (NEI), the American Optometric Association, and other organizations. These resources feature easy-to-read information and are free to access, download, and share. Resources can be accessed through the online catalog here.

Looking for more information on a topic included in this collection? View our search tips page for guidance on searching the online catalog, or contact the OMH Knowledge Center directly for research assistance.

 

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