Tuesday, February 23, 2021

Monoclonal Antibodies against MERS Coronavirus Show Promise in Phase 1 NIH-Sponsored Trial

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Tuesday, Feb. 23, 2021

Monoclonal Antibodies Against MERS Coronavirus Show Promise in Phase 1 NIH-Sponsored Trial

MERS coronavirus

A Phase 1 clinical trial of two monoclonal antibodies (mAbs) directed against the coronavirus that causes Middle East respiratory syndrome (MERS) found that they were well tolerated and generally safe when administered simultaneously to healthy adults. Preclinical studies in mice showed that the mAb combination reduced virus levels in the lungs of animals that were exposed to the virus both before and after mAb administration. The mAbs were discovered and developed by scientists at the biopharmaceutical company Regeneron, located in Tarrytown, New York. The trial was sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. 

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