Tuesday, February 23, 2021 Mouse Study Shows Bacteriophage Therapy Could Fight Drug-Resistant Klebsiella pneumoniae A human neutrophil interacting with Klebsiella pneumoniae (pink), a multidrug–resistant bacterium that causes severe hospital infections. Credit: NIAID NIAID scientists have used two different bacteriophage viruses, individually and combined, to successfully treat research mice infected with multidrug-resistant Klebsiella pneumoniae ST258. Using viruses instead of antibiotics to tame troublesome drug-resistant bacteria is a promising strategy, known as bacteriophage or "phage therapy." In this work the scientists isolated the phages from raw sewage that they screened for viruses that would infect ST258—an indication that phages can be found just about any place. Each of the three experimental treatment regimens helped the mice recover from ST258 infection. Unfortunately, the scientists also found that ST258 bacteria recovered in the blood and tissue samples of phage-treated mice already had begun developing phage resistance, something they are continuing to investigate. National Institute of Allergy and Infectious Diseases  |  National Institutes of Health Update your subscriptions, modify your password or e-mail address, or stop subscriptions at any time on your Subscriber Preferences Page. You will need to use your e-mail address to log in. If you have questions or problems with the subscription service, please contact Subscriber Help. This service is provided to you at no charge by National Institute of Allergy and Infectious Diseases (NIAID).                             This email was sent to myhcistech.healthnews360@blogger.com using GovDelivery Communications Cloud on behalf of: National Institute of Allergy and Infectious Diseases · 5601 Fishers Lane · Bethesda, MD 20892 · 1-866-284-4107