Friday, October 22, 2021 Repurposed Drug, Rottlerin, Protects Neurons Against La Crosse Virus This image from a fluorescent microscope shows La Crosse virus (purple) assembled in the Golgi (yellow outline) before leaving the neuron. The natural compound Rottlerin prevents virus from leaving the Golgi and prevents spread to other neurons. (NIAID)   La Crosse virus (LACV) can cause serious brain swelling and neurological disease, particularly in children. The disease, which has no vaccine or treatment, causes about 70 annual hospitalized cases per year in the Eastern U.S. The CDC considers LACV, which is spread by the eastern treehole mosquito, to be highly under diagnosed and under reported. In a new study in Nature Microbiology, NIAID scientists in Montana and NCATS scientists in Maryland screened more than 3,800 compounds for activity against LACV. They found one, Rottlerin, a natural compound isolated from the Kamala tree, that was an effective treatment against LACV infection in mouse and cerebral organoid models. National Institute of Allergy and Infectious Diseases  |  National Institutes of Health Update your subscriptions, modify your password or e-mail address, or stop subscriptions at any time on your Subscriber Preferences Page. You will need to use your e-mail address to log in. If you have questions or problems with the subscription service, please contact Subscriber Help. This service is provided to you at no charge by National Institute of Allergy and Infectious Diseases (NIAID).                             This email was sent to myhcistech.healthnews360@blogger.com using GovDelivery Communications Cloud on behalf of: National Institute of Allergy and Infectious Diseases · 5601 Fishers Lane · Bethesda, MD 20892 · 1-866-284-4107