Friday, February 4, 2022

Original mRNA-1273 Boost Provides Protection Equal to Omicron-Specific Boost

The study provides insights into whether vaccines will need matching to future SARS-CoV2 variants.
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Friday, February 4, 2022

Original mRNA-1273 Boost Provides Protection Equal to Omicron-Specific Boost

TEM image of SARS-CoV-2

The original mRNA-1273 COVID-19 vaccine, developed by NIAID and Moderna scientists, performed equally well when compared to an mRNA-Omicron specific booster in animal studies. NIAID scientists and colleagues, in a study not yet peer reviewed but posted online because of its timeliness, tested both booster vaccines in animals roughly nine months after the animals had received two mRNA-1273 doses. Both boosts provided comparable increase in neutralizing antibodies against Omicron and high-level protection in the lungs against an Omicron challenge. The study affirmed in the animals what has been observed in people, that boosting with mRNA-1273 protects the lungs against severe infection by Omicron. The study provides insights into whether vaccines will need matching to future SARS-CoV2 variants.

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