Wednesday, September 20, 2023

Clinical Trial of HIV Vaccine Begins in United States and South Africa

A trial of a preventive HIV vaccine candidate has begun enrollment in the United States and South Africa.
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Wednesday, September 20, 2023

Clinical Trial of HIV Vaccine Begins in United States and South Africa

Transmission electron micrograph of HIV-1 virus particles from infected H9 cells, produced in cell culture. Credit: NIAID

A trial of a preventive HIV vaccine candidate has begun enrollment in the United States and South Africa. The Phase 1 trial will evaluate a novel vaccine known as VIR-1388 for its safety and ability to induce an HIV-specific immune response in people. NIAID has provided scientific and financial support throughout the lifecycle of this HIV vaccine concept and is contributing funding for this study along with the Bill & Melinda Gates Foundation and Vir Biotechnology, Inc., based in San Francisco. The vaccine uses a cytomegalovirus (CMV) vector, meaning a weakened version of CMV delivers the HIV vaccine material to the immune system without causing disease in study participants. NIAID has funded the discovery and development of the CMV vaccine vector since 2004. This trial is sponsored by Vir and conducted through the NIAID-funded HIV Vaccine Trials Network as study HVTN 142.

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