Tuesday, July 9, 2024 Innate Immune Activation is Linked to Harmful Inflammation in Kaposi Sarcoma Herpesvirus-Associated Disorders, NIAID Study Finds This electron microscopic image depicted numbers of human herpesvirus-8 (HHV-8) particles, the causative agent of Kaposi's sarcoma, which had been grown in cell culture. These extracellular particles are composed of an inner nucleocapsid, surrounded by an envelope with a layer of tegument apposed to the envelope. Credit: CDC Kaposi sarcoma herpesvirus (KSHV) associated disorders (KAD) are linked to activation of innate immune processes that cause detrimental inflammation in people with KAD and HIV, a NIAID study found. KAD include Kaposi sarcoma, primary effusion lymphoma, KSHV-associated multicentric Castleman disease, and KSHV-inflammatory cytokine syndrome. KAD tend to affect people whose immune systems are suppressed. The findings, published in the journal Blood, may inform novel treatments for this complex group of disorders. Learn More National Institute of Allergy and Infectious Diseases  |  National Institutes of Health

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