Tuesday, September 10, 2024 SARS-CoV-2 Rapidly Evolves in People with Advanced HIV Creative layout featuring 3D-printed SARS-CoV-2 virus particles, depicted in varying colors to suggest variants. Credit: NIAID NIAID researchers found that SARS-CoV-2—the virus that causes COVID-19—rapidly evolves in people with HIV who have weakened immune systems. They used cutting-edge technology to examine genes from SARS-CoV-2 in people with and without HIV who also had COVID-19, looking at the different copies of the virus in individuals over time. They found that people with advanced HIV—as defined by reduced numbers of immune cells called CD4+ T cells—had dozens of SARS-CoV-2 variants in their bodies, compared to just one major variant in most people without HIV and people with HIV who had higher numbers of CD4+ T cells. The study revealed how some viral variants may emerge in people with weakened immune systems. Learn More National Institute of Allergy and Infectious Diseases  |  National Institutes of Health

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