Tuesday, December 5, 2023

Outcomes of Very Early Treatment for Infants Who Acquired HIV In Utero

Study analysis shows outcomes for infants with HIV who started antiretroviral therapy very early in life.
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Tuesday, December 5, 2023

Outcomes of Very Early Treatment for Infants Who Acquired HIV In Utero

Blue and black granulated matter with a row of dark pink spheres at the edge, running diagonally across the length of the image.

Colorized transmission electron micrograph of HIV-1 virus particles (red) budding and replicating from an H9 T cell (blue). The virus particles are in various stages of maturity, which accounts for differences in shape. Captured at the NIAID Integrated Research Facility in Fort Detrick, Maryland. Credit: NIAID

Long-term data from a study implemented by the NIH-funded International Maternal Pediatric Adolescent AIDS Clinical Trials network showed very early antiretroviral therapy (ART) for infants who acquired HIV in utero enabled some infants to sustain viral suppression for more than two years. Of children whose HIV remained suppressed, a majority continued to show no evidence of the latent HIV reservoirs that contribute to lifelong persistent infection. The next phase of the study involves a planned interruption in ART for children meeting prespecified criteria to observe whether they remain free of HIV, while closely monitoring their overall health. The latest study findings are published in The Lancet HIV.

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