Immunology News: Activated G Protein Bypasses Cyclic AMP to Regulate Human Immune Cells

This leads to multi-organ dysfunction, major immune dysregulation, and life-threatening autoimmunity in people.

Thursday, September 19, 2024 Activated G Protein Bypasses Cyclic AMP to Regulate Human Immune Cells Illustration of molecular pathway in normal T cells (left panel) and in T cells with activating G-protein mutations (center panel). Illustration of diseases found in people with the mutations (right panel). Credit: NIAID NIAID scientists have uncovered how a so-called "G protein" with rare, activating mutations makes T cells hyperactive and abnormally abundant by bypassing a key signaling molecule. These effects on T cells lead to multi-organ dysfunction, major immune dysregulation, and life-threatening autoimmunity in people. The unusual G-protein behavior could potentially be exploited for the development of T-cell based cancer therapies, according to the researchers. Their findings were published today in the journal Science. National Institute of Allergy and Infectious Diseases  |  National Institutes of Health Update your subscriptions, modify your password or e-mail address, or stop subscriptions at any time on your Subscriber Preferences Page. You will need to use your e-mail address to log in. If you have questions or problems with the subscription service, please contact Subscriber Help. Your subscription may be removed if you do not open our emails for a six-month period.  This service is provided to you at no charge by National Institute of Allergy and Infectious Diseases (NIAID).                             This email was sent to myhcistech.healthnews360@blogger.com using GovDelivery Communications Cloud on behalf of: National Institute of Allergy and Infectious Diseases · 5601 Fishers Lane · Bethesda, MD 20892 · 1-866-284-4107